![]() These findings have opened the door for further research into the genetic causes of AMD, as well as the potential for developing future AMD treatments targeting the genes regulating cell degeneration. "Generally, high oxidative stress is bad for cells-and could contribute to RPE degeneration." "As you get older, there's a build-up of oxidative stress in cells, which affects many cell types including RPE," says Wong. Oxidative stress is a natural process in our bodies that can happen when our cells use energy. "It turns out both of these genes play roles in regulating the oxidative stresses, which is a key mechanism in aging of the retina," Wong says. By turning off certain genes in cells, researchers can study its effect and see what role these genes play. Genes provide the instructions for many biological processes in our cells. Then, using cutting-edge gene editing technology, Wong and his team "switched off" the two genes and discovered they had a key role in maintaining cell health. To determine the genes' function, the team created a model of human RPE cells in the lab. Previous studies have identified many genes that are linked to AMD, though Wong's team are the first to investigate the roles of two specific genes, TMEM97 and POLDIP2, in human retinal pigmented epithelial cells (RPE)-the cells affected in AMD. Identifying and understanding the genes associated with a higher risk of developing AMD can help researchers develop treatments that target the underlying causes of the disease. It affects the macula-the central part of the retina at the back of the eye-causing cells to gradually break down, often leading to blurred central vision. The research is a collaboration between CERA, the University of Melbourne, Lions Eye Institute and other national collaborators.ĪMD is one of the world's leading causes of blindness, yet we still don't understand all the mechanisms that lead to this disease. The findings, published in Aging and the International Journal of Molecular Science, provide a deeper understanding of the underlying causes of AMD and help prioritize new gene targets for treatments.
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These are noted in the Starting conditions column of the list.Īchievements can be earned while playing older versions of the game (1.6 and above) as long as the given achievement was present in that version. Most achievements have Starting conditions which have to be fulfilled when starting the campaign before any player input.Some achievements don't allow the player to play as a released vassal and this also prohibits playing as a released colonial nation and switching to a different country in an event(forming countries via event is allowed).Most achievements don't allow any custom nations on the map(exceptions are noted in the list).All but 4 achievements require that the game was started at 11 November 1444(exceptions are noted in the list).Nations must be set to “Normal setup” or “Historical setup”.Province Tax and Manpower must be set to “Normal values”.Limited country forming must be set to “Yes”.Lucky nations must be set to “Historical”.Difficulty must be set to “Normal” or higher.Most graphical, interface or music mods don't alter the checksum and thus are allowed. So no gameplay altering mod may be active and the game files must not be corrupted or modified in a different way. The game files must have the correct checksum for the game version.To gain achievements one needs to play in ironman and also obey the following requirements(ironman itself is still possible even when not fulfilling these requirements): The below list groups the various achievements by a difficulty level as assessed by the wiki editors (uncategorized - UC - achievements haven't been assessed yet). taking all of Asia's grassland as Kale before the age of absolutism). signing a royal marriage with another country), while some are extremely difficult (e.g. ![]() The difficulty of each achievement varies some achievements are very easy (e.g. It is possible to see the achievements sorted by the percentage of users that managed to complete each achievement by going to the game's global achievements at Steam (for more precise numbers one can use the Steam web API). Achievements have no in-game effects the achievement just pops up in-game and then added to the player's Steam profile. Please help with verifying or updating older sections of this article.Īt least some were last verified for version 1.34.įor tips and tricks on how to complete an achievement, see the achievements category.ĮU4 has 354 different achievements, all using the Steam achievements mechanics. And I couldn't wait to get up there that summer and live there all summer. ![]() My cousin that lived in the Lancaster area was very into punk rock, very into skateboarding. And I was very close with all of my cousins. I went up to the Lancaster, Pa., area, and I'm up there and some of my family - my mother's sister, my aunt and uncle moved up there with their kids. On how he became involved with neo-Nazi activities Once I got out there and noticed that the 'us' was very, very small and the 'them' was very, very big - and there was no one helping me - and I think that's where it started." So it wasn't this big 'I hate them.' It was just an us-them. Growing up in South Philly, where we just had this Irish pride thing, I never really thought of the other races or the other races who lived around us as inferior or as much trouble because most of the kids - and most of the fistfights you got into - were with other Irish kids. On how attending a predominantly African-American middle school influenced his later racial hatred I said 'I don't have any information on anybody, but I just need to let you know what it's like.' And of course they wanted to listen, because the Oklahoma City bombing had happened." I felt OK on the outside, but I felt so evil inside. Throughout my life, even when I was tattooed up and wanting to be a skinhead, I felt like maybe I was bad on the outside. His transformation solidified, he tells Dave Davies, after the Oklahoma City bombing, when he saw the iconic photo of a firefighter cradling a lifeless girl in his arms. While in prison, Meeink says, he was exposed to people from a variety of ethnic and racial backgrounds and started reevaluating his own racist beliefs. ![]() He had his own public access talk show, called The Reich, he appeared on Nightline and other media outlets as a spokesman for neo-Nazi topics, and he regularly recruited members of his South Philadelphia neighborhood to join his skinhead gang.Īt 18, Meeink spent several years in prison for kidnapping one man and beating another man senseless for several hours. As a teenager, Frank Meeink was one of the most well-known skinhead gang members in the country. ![]() ![]() Advanced Uninstaller PRO will automatically remove EASEUS Data Recovery Wizard Professional 5.0.1 Demo. Confirm the uninstall by clicking the Uninstall button.
![]() However, its heavier weight and handling characteristics may be a concern for some riders. Overall, the RadCity 5 Plus offers several improvements over its predecessor, such as hydraulic brakes, a geared rear-hub motor, and an integrated battery design. This could be a concern for riders who need to carry the bike up and down stairs regularly. Lastly, the RadCity 5 Plus is relatively heavy, weighing in at 64lbs for the step-thru model and 65lbs for the high-step model. To be honest, I’m disappointed that they changed the geometry because I really enjoyed riding my RadCity 4 and found it slightly uncomfortable riding the 5. That being said, this isn’t a deal breaker.Īdditionally, the wheelbase is shorter, and the riding posture is more upright compared to the RadCity 4, leading to a slightly more jerky or squirrelly handling experience. Having owned both types, my preference is for mid-drive motor with a torque sensor because it provides a more natural bicycle feel. It has a rear-hub motor and cadence sensor rather than a mid-drive motor and torque sensor. The RadCity 5 Plus does have a few drawbacks. The rain fenders provide excellent coverage, which is particularly beneficial for riders in wet climates. This e-bike also comes with an integrated rear rack that has a high capacity, making it easy to attach a toddler seat or carry other gear. These are great tires and I’ve never had a flat on my RadCity 4 despite 1,000+ miles. The RadCity 5 Plus is equipped with 2-inch wide puncture-resistant tires that help protect against flats. I find the throttle especially useful when getting started at a green light. ![]() The throttle feature offers an additional level of convenience, particularly for riders who may need a quick boost of power. The easy-to-read LCD screen displays essential information like speed, power output, and odometer readings, making it user-friendly for all riders. With a range of 28-50 miles, the RadCity 5 Plus is suitable for a variety of commutes and recreational rides. The battery has also been redesigned to be more integrated into the frame, giving the bike a sleeker appearance. This motor is geared, providing more torque at lower speeds, which is particularly helpful for hill climbing and acceleration. One of the other upgrades on the 5 is the new geared rear-hub 750 watt motor. These brakes provide a smoother and more responsive braking experience compared to the mechanical disc brakes found on the RadCity 4. It features an upgrade from its predecessor with the addition of hydraulic brakes. The RadCity 5 Plus is a Class 2 e-bike with a throttle and pedal assist up to 20mph.
![]() Soft but the bright light color scheme of light blue, yellow, and white with a huge variety of presentation options. Creative Light Bulb Free PowerPoint TemplateĪ great free 36 unique slide template imaginatively mixing the metaphor of a creative light bulb and a school pencil. To keep the attention and keep on a theme the pages have mixed borders of biro penned doodles of school icons. An exercise book theme, with 23 square lined pages that cover everything you could possibly need, including maps, infographics, charts, images, etc. ![]() Friar Free Education PowerPoint TemplateĪ clean, clear look from this Free Friar Education template for teachers. This template can be used for Google slides as well. ![]() You can also simulate the handwriting with chalk. Great realistic background board with fantastic hand-drawn chalk font, fully editable with lots of scopes. Take your students back to the classroom with this free green chalkboard PowerPoint template. Free Chalkboard PowerPoint Template for Teachers Added to this the style of fun creative fonts and text bubble will capture the attention in this flexible easy to edit PowerPoint or Google Slide show. A simple design with different waving multicultural children characters in the bottom right corner. Lucius Free Teaching PowerPoint TemplateĪ 23 different layout slide presentation template specifically designed for very young learners, nursery or kindergarten age. It is fully editable for your subject and will grab the attention right from the first slide. A green color scheme with blue, orange, and purple accents and accompanying cool chalkboard effect school icons border. Elijah Free Teaching PowerPoint TemplateĪ 25 school theme slide show a PowerPoint template (compatible with Google Slides) with plenty of text boxes for content but also areas for graphs, comparison charts, images, and other infographics. GraphicMama has decided to give this template away absolutely free to help teachers with online lessons, so you don’t have to pay a penny. It is available for PowerPoint, but easily imported into Google Slides, and even used in Google Classroom. This free presentation template is perfect for online lessons – you can find slides for math, literature, geography, biology, and chemistry, plus infographic slides for practice and infographics. They are available in 2 color schemes, making a total of 40 slides. Free Educational Presentation Templates for Online LessonsĢ0 Slides especially made for online lessons. Let’s not waste any more time, you have things to do!ĭo you want to learn 9 creative ways to use technology in education? 1. ![]() Here we present 20 fantastically free Google Slides and PowerPoint Presentation Templates that will wow your students and impress the senior management at the same time as well as saving you time and effort. The last thing you need is a class laughing at your computer skills. Preparation of materials is vital especially if you are now an online teacher and whilst your main job is the content you still want the look to be professional. You can use them as a base for a whole lesson, talking through and discussing issues raised on each slide, you can run it through as a presentation in its own right and even share the file so remote learners can watch it back.Īs teachers we understand that your time is precious, planning, marking, assessing, grading, mountains of paperwork, and of course, lest we forget, continuous learning and development. Working from home remotely or teaching in the classroom, slideshows and presentations are a great way to get key information across in a visually exciting and memorable way. Update July 2, 2021: We’ve updated the article with new and fresh free templates for teachers These readme files include information about how to use these images appropriately in your applications. Readme files are also included in the PDF format for the Common Elements and Icon types. The Visual Studio 2013 image library includes legacy images (from previous versions including VS2012), new images for 2013, and the. To access the files in the image library, download VS2012 Image Library.zip and extract the folders and images from the zip file.īy downloading and using the Microsoft Visual Studio 2012 Image Library you agree to the terms of the Microsoft Software License Terms ( link). The Visual Studio 2012 image library includes five main categories of images: Common Elements, Actions, Annotations, AppIcons and Objects. Microsoft Download Manager is free and available for download now. It also allows you to suspend active downloads and resume downloads that have failed. ![]() It gives you the ability to download multiple files at one time and download large files quickly and reliably. ![]() The Microsoft Download Manager solves these potential problems. You might not be able to pause the active downloads or resume downloads that have failed. (You would have the opportunity to download individual files on the "Thank you for downloading" page after completing your download.)įiles larger than 1 GB may take much longer to download and might not download correctly. In this case, you will have to download the files individually. You may not be able to download multiple files at the same time. If you do not have a download manager installed, and still want to download the file(s) you've chosen, please note: ![]() Stand-alone download managers also are available, including the Microsoft Download Manager. Many web browsers, such as Internet Explorer 9, include a download manager. Generally, a download manager enables downloading of large files or multiples files in one session. ![]() Usually commercial software or games are produced for sale or to serve a commercial purpose. Even though, most trial software products are only time-limited some also have feature limitations. After that trial period (usually 15 to 90 days) the user can decide whether to buy the software or not. Trial software allows the user to evaluate the software for a limited amount of time. Funciona para dispositivos iOS, ordenadores Windows y PC Mac. Demos are usually not time-limited (like Trial software) but the functionality is limited. Fliqlo de Yuji Adachi es una aplicación de salvapantallas de pago que te permite ver la hora. In some cases, all the functionality is disabled until the license is purchased. Demoĭemo programs have a limited functionality for free, but charge for an advanced set of features or for the removal of advertisements from the program's interfaces. In some cases, ads may be show to the users. Basically, a product is offered Free to Play (Freemium) and the user can decide if he wants to pay the money (Premium) for additional features, services, virtual or physical goods that expand the functionality of the game. This license is commonly used for video games and it allows users to download and play the game for free. There are many different open source licenses but they all must comply with the Open Source Definition - in brief: the software can be freely used, modified and shared. Programs released under this license can be used at no cost for both personal and commercial purposes. Open Source software is software with source code that anyone can inspect, modify or enhance. Freeware products can be used free of charge for both personal and professional (commercial use). Fliqlo is free software.Freeware programs can be downloaded used free of charge and without any time limitations. Choose between the AM/PM and the 24-hour format. Getting Fliqlo up and running on a Windows PC is an effortless task. Need a free screensaver that looks like a flip clock? In that case, you need Fliqlo!įliqlo is available for Windows and Mac. Fliqlo is available for Microsoft’s Windows and for Apple’s Mac OS X. From it you can access Fliqlo’s settings (the settings menu I mentioned above), you can preview Fliqlo, and you can choose for how long the operating system will wait until it brings up the Fliqlo screensaver.įliqlo is free software. Once the installation process completes, the Screen Saver Settings dialog will show up. ![]() Run an installer and Fliqlo will be installed on your Windows PC. Click it and Fliqlo will revert to its default settings. If you’d like to return to the default size and time format, then you need to know that the settings menu features a Reset All button. There’s a slider that you can use to shrink the size down to 25% or increase the size up to 125%. Speaking about the settings menu, it also lets you pick a custom size for the flip clock. If you don’t like that format, you can switch to the army-style 24-hour format from the Settings menu. By default, it presents the time in AM/PM format. And because the operating system doesn’t have such an option, Fliqlo has been developed to fill that void.įliqlo is a screensaver for Microsoft’s Windows operating system, a screensaver that looks like a flip clock. What it does not have is a screensaver that looks like a flip clock. The Windows operating system comes with a built-in option to display the time, to present a clock as the screensaver. ![]() Remind yourself why you are doing this: in order to become a physician. However, stress can really build up in the final days leading up to the MCAT, and you need to plan to deal with it.įirst, keep the big picture in mind. Most people perform better when they have a bit of an “edge,” and rise to the occasion. Test anxiety is a normal part of the MCAT, and it can actually work in your favor. What kind of scratch material is provided? What kind of writing instrument?.How many bathrooms are there? Where are they located?.How long does it take to check back into the testing room after breaks?.Is there a refrigerator or microwave available?.What are the lockers/storage bins like?.Am I allowed to put on/take off layers of clothing in the testing room?.What is the temperature like in the testing room?.Each test center is slightly different, so make sure you know exactly what yours will be like: Consider the following, and add any other questions you might have. You can make up a list of questions for the test center staff so that you know exactly what to expect. No food or beverages are allowed in the test room, so having a plan for what you’ll bring along for the breaks is critical to your endurance.įinally, consider taking a trip to the test center itself to become familiar with the environment, or calling before test day. Have water or a sports drink at every break, whether you feel thirsty or not. Most importantly, you’ll need to stay hydrated. Don’t forget to have something for the final break to help you get through the last section of the test. For lunch, have a small sandwich such as peanut butter or ham and cheese. Good choices are fruits (such as a banana or sliced apple), granola bar, cheese, or nuts. Bring high-energy snacks that are quick, neat, and some of your favorites having something you like will help you manage stress. Snacks, lunch, and beverages are part of making it through a long and challenging day. Next, plan out what you’ll do in each break. You might need to change your coffee/tea/caffeinated beverage routine to match what you’ll encounter on test day itself. Also, keep in mind that no food or drinks are allowed in the test room itself. Match your meals and breaks to the test day schedule. That way, it won’t be a big change for you. Start going to bed and getting up at the same time that you’ll need to on the day of the MCAT. You need to prepare for this in advance, and have a plan for all aspects of test day.įirst, set up your body’s Circadian rhythm to match test day. Between the test sections and the breaks, you’ll spend almost seven and a half hours taking the MCAT. One overlooked aspect of the MCAT that requires preparation is the physical drain of the test. ![]() Just wait for your party to kill the troll and keep dodging. You probably won’t be able to attack the troll and keep your stamina up at the same time. Depending on the space you have, you may have to go past the troll and lead it to the back of the troll cave.īe very wary of your stamina and stay patient. You can back up just enough to avoid the troll attacks while regaining stamina. The space you covered at the beginning of the encounter is your buffer zone. I have found success starting the dodge-roll right as the troll’s attack is about halfway. It telegraphs attacks pretty early and you’ll have plenty of warning, timing is the only challenge. You’re going to try and dodge-roll each of the troll’s attacks - using the few moments you’re invulnerable (i-frames) to survive. The more room you have to fall back during the fight, the easier your job will be. ![]() The Tank’s RoleĪs the tank, you will have the hardest job in a troll cave.Īfter the sneak attack volley, you need to close the distance and get in the troll’s face as quickly as possible. ![]() If your tank gets hit, someone should be ready to swap in. Make sure everyone has eaten plenty of food and is hearty enough to take at least one full attack. The easiest way to defeat a troll in its troll cave is to use one person as the tank, dodging the troll’s huge attacks, while the rest of the party sits by the entrance and uses ranged weapons. The normal troll fighting strategy (kiting) doesn’t work because the cave is too small. We recommend bringing a friend when entering troll caves and always try to unleash a volley of sneak attacks. If things get dicey, you can always leave the cave and the troll will not follow you. You will have very little room to maneuver around the troll during combat. Trolls are especially dangerous in their cave because all troll caves are small. Troll Caves are big caves with a troll in them - pretty self-explanatory. |
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